CJC-1295 without DAC Research Information
Modified GRF (1-29) / Short-Acting GHRH Analog
For Natural Pulsatile Growth Hormone Research
⚠️ Important: This information is for educational and research purposes only. Always consult with a qualified healthcare professional before use.
📑 Contents
🔬 What is CJC-1295 without DAC?
CJC-1295 without DAC (also known as Modified GRF 1-29 or Mod GRF) is a synthetic 29-amino acid peptide analog of Growth Hormone-Releasing Hormone (GHRH) that does not contain a Drug Affinity Complex (DAC) moiety [2]. This results in a significantly shorter half-life of approximately 30 minutes compared to the DAC-conjugated version [1][2].
CJC-1295 without DAC is often preferred in research settings for its ability to mimic the body's natural pulsatile release pattern of growth hormone, which may reduce the risk of receptor desensitization compared to sustained GH elevation [1][5]. It is available in pen and freeze-dried vial formulations for research purposes.
⚡ How CJC-1295 without DAC Works
CJC-1295 without DAC works through a targeted mechanism to stimulate natural, pulsatile growth hormone release:
GHRH Receptor Binding
Binds to GHRH receptors on pituitary somatotroph cells, stimulating GH synthesis and release in a pulsatile pattern [2]
Short Half-Life
~30 minute half-life allows for rapid clearance and natural pulsatile GH release pattern [1][5]
Physiologic Mimicry
Preserves the natural pulsatile secretion pattern of GH, reducing receptor desensitization risk [5][7]
CJC-1295 without DAC induces an increase in GH concentrations of 2- to 10-fold in a pulsatile manner, providing a more physiological approach to growth hormone research compared to the sustained elevation seen with the DAC version [1][5].
📋 Research Applications
📊 Clinical Studies
Growth Hormone Elevation Studies
- GHRH analogs like CJC-1295 can increase GH levels by 2- to 10-fold and IGF-1 levels by 1.5- to 3-fold [1][5]
- In rats, a single subcutaneous injection of CJC-1295 increased plasma GH levels, peaking at 30 minutes [3]
- CJC-1295 increases GH secretion in primary rat anterior pituitary cells at picomolar to micromolar concentrations [2][8]
Pharmacokinetics
- CJC-1295 without DAC has a half-life of approximately 30 minutes [1][5]
- Rapid clearance allows for multiple daily dosing to align with natural GH pulses [1][4]
Clinical History
💉 Interactive Dosing Guide
Select your vial size and dose to see the corresponding volume, clicks, dosing frequency, and how many doses per vial:
🖊️ Step 1: Select Your Vial Size
💊 Step 2: Select Your Dose
Vial Size
5mg Vial
Selected Dose
50 mcg
Doses per Vial
100 doses
Pen Clicks
3 clicks
Volume
0.03 mL
Protocol Level
Level 1 (Starting)
Recommended Schedule
1-3 times daily - Pulsatile Protocol
⚠️ Do not change your dose unless advised by a qualified professional.
📋 Protocol Level Summary
Based on research protocols: 100-500 mcg, 1-3 times daily. Common schedule: 100 mcg before bed, often combined with Ipamorelin [1][4][7].
| Protocol Level | Target Dose | Frequency | 5mg Clicks | 10mg Clicks | Who It\'s For |
|---|---|---|---|---|---|
| Level 1 (Starting) | 50 mcg | 1-3x daily | 3 clicks | 1.5 clicks | New users, first 2 weeks |
| Level 2 (Standard) | 100 mcg | 1-3x daily | 6 clicks | 3 clicks | After 2 weeks, maintenance |
| Level 3 (Advanced) | 200 mcg | 1-3x daily | 12 clicks | 6 clicks | If more response needed |
| Level 4 (Maximum) | 300-500 mcg | 1-3x daily | 18-30 clicks | 9-15 clicks | Experienced users only |
⚠️ Do not change your dose unless advised by a qualified professional.
💉 Vial Users (Insulin Syringe)
Add 3mL of bacteriostatic water to your freeze-dried vial and mix gently. After reconstitution, use the table below to draw your dose:
Vial Size
5mg vial with 3mL bac water
| Dose | Frequency | 5mg Units | 10mg Units | Protocol Level |
|---|
⚠️ Always use a new sterile needle and syringe for each injection.
⚠️ Safety & Precautions
CJC-1295 without DAC offers a shorter half-life, which may reduce the risk of receptor desensitization compared to the long-acting DAC version [1][5]. The short half-life also means it is more forgiving for initial research use—if any adverse effects occur, the peptide clears from the system within hours [7].
- Injection site reactions: Redness, tenderness, or pain at the injection site
- Flushing or headache: Occasionally reported with GHRH analogs
- Dose-dependent effects: Higher doses may increase risk of side effects
Do not use if you:
- Are allergic to CJC-1295 or any ingredients
- Are pregnant or breastfeeding
- Have known hypersensitivity to GHRH or related compounds
⚠️ Warning: CJC-1295 is not FDA-approved for any indication. It is classified as a prohibited substance by WADA [9]. If you experience severe allergic reactions, difficulty breathing, or signs of anaphylaxis, seek immediate medical help.
📚 References
- CJC-1295 Peptide Guide: Benefits, Dosage & Safety Tips. Peptides Unleashed. 2025. [1]
- CJC-1295 (acetate) Product Information. GlpBio. [2]
- FDA Evaluation of CJC-1295-related bulk drug substances for 503A Bulks List. 2024. [3]
- CJC-1295 Dosage and Cycle Length. Imperium Health. 2025. [4]
- CJC-1295 NO DAC Product Page. Beverly Hills Rejuvenation Center. 2025. [5]
- How to Take CJC-1295 Without Wasting Your Money. Holistic Nootropics. 2026. [7]
- CJC-1295 Product Information. 10xchem.com. [8]
- CJC-1295 Use in Sports and Military Rules Explained. BSCG. 2026. [9]
This information is for educational and research purposes only. Always consult with a qualified healthcare professional.
Last updated: July 2026