CJC-1295 without DAC + Ipamorelin Blend Research Information
GHRH Analog + GHSR Agonist Blend
For Synergistic Growth Hormone Research
⚠️ Important: This information is for educational and research purposes only. Always consult with a qualified healthcare professional before use.
📑 Contents
🔬 What is CJC-1295 without DAC + Ipamorelin Blend?
The CJC-1295 without DAC + Ipamorelin blend is a synergistic combination of two peptides that work through different but complementary pathways to stimulate natural growth hormone release [2][3][9]. This blend pairs a GHRH analog with a GHSR agonist to amplify both the frequency and duration of natural GH output [2][9].
CJC-1295 without DAC is a modified GRF (1-29) analog that extends each GH pulse, while Ipamorelin is a selective growth hormone secretagogue that triggers a clean GH pulse without raising cortisol or prolactin [2][4][9]. Together, they are often considered the most commonly recommended peptide stack for research on lean muscle growth and recovery [9]. This blend is available in pen and freeze-dried vial formulations for research purposes.
⚡ How CJC-1295 without DAC + Ipamorelin Blend Works
This blend works through two distinct but complementary mechanisms to stimulate growth hormone release:
CJC-1295 (GHRH Analog)
Binds to GHRH receptors on pituitary somatotroph cells, extending the duration of each natural GH pulse [2][4][9]
Ipamorelin (GHSR Agonist)
Mimics ghrelin and triggers GH release from the pituitary without significantly raising cortisol or prolactin [2][4][9]
CJC-1295 amplifies the GH-releasing signal, while Ipamorelin triggers the actual release—a synergy that can produce greater GH elevation than either peptide alone [2][9]. The CJC-1295 without DAC version has a short half-life of approximately 30 minutes, preserving the body's natural pulsatile pattern of GH release and reducing the risk of receptor desensitization [2][5].
📋 Research Applications
Muscle Growth Research
Studying IGF-1 elevation and protein synthesis for lean muscle development [9]
📊 Clinical Studies
Clinical Studies on CJC-1295 (Teichman et al., JCEM 2006)
- A single injection of CJC-1295 increased mean GH concentrations by 2- to 10-fold [1][2]
- IGF-1 elevations of 1.5- to 3-fold persisted for 9 to 11 days [1][2]
- The "no DAC" version has a short half-life of approximately 30 minutes [2][5]
Synergistic Effects of the Blend
- CJC-1295 extends each GH pulse while Ipamorelin triggers the release [4][9]
- Together, they amplify both the frequency and duration of natural GH output [9]
- Ipamorelin has a half-life of approximately 120 minutes and provides selective GH release without cortisol elevation [4][11]
- Prefers the no-DAC version because chronic GHRH stimulation risks receptor desensitization [5]
Research Protocols
💉 Interactive Dosing Guide
Select your blend size and dose to see the corresponding volume, clicks, dosing frequency, and how many doses per vial:
🖊️ Step 1: Select Your Blend Size
This is a 1:1 blend (5mg CJC-1295 + 5mg Ipamorelin = 10mg total)
Blend Size
10mg Blend (5+5)
Selected Dose
100 mcg each
Doses per Vial
50 doses
Pen Clicks
6 clicks
Volume
0.06 mL
Protocol Level
Level 2 (Standard)
Recommended Schedule
1-2 times daily - 5 days on, 2 days off
⚠️ Do not change your dose unless advised by a qualified professional.
📋 Protocol Level Summary
Based on research protocols: 100-200 mcg each, 1-2 times daily, 5 days on / 2 days off [1][4][9][11].
| Protocol Level | Target Dose | Frequency | Pen Clicks | Volume (mL) | Who It\'s For |
|---|---|---|---|---|---|
| Level 1 (Starting) | 50 mcg each | 1x daily | 3 clicks | 0.03 mL | New users, first 2 weeks |
| Level 2 (Standard) | 100 mcg each | 1-2x daily | 6 clicks | 0.06 mL | After 2 weeks, maintenance |
| Level 3 (Advanced) | 150 mcg each | 1-2x daily | 9 clicks | 0.09 mL | If more response needed |
| Level 4 (Maximum) | 200 mcg each | 1-2x daily | 12 clicks | 0.12 mL | Experienced users only |
⚠️ Do not change your dose unless advised by a qualified professional.
💉 Vial Users (Insulin Syringe)
Add 3mL of bacteriostatic water to your freeze-dried vial and mix gently. After reconstitution, use the table below to draw your dose:
Vial Size
10mg blend vial (5mg CJC-1295 + 5mg Ipamorelin) with 3mL bac water
| Dose | Frequency | Units on Syringe | Volume (mL) | Protocol Level |
|---|
⚠️ Always use a new sterile needle and syringe for each injection.
⚠️ Safety & Precautions
The CJC-1295 + Ipamorelin blend has been studied in clinical and research settings. The "no DAC" version has a short half-life (~30 minutes), which may reduce the risk of receptor desensitization compared to the long-acting DAC version [2][5].
- Injection site reactions: Redness, tenderness, or pain at the injection site [1][4]
- Flushing, headache, or dizziness: Occasionally reported with GHRH analogs [2]
- Nausea: Mild and transient in some cases [1][4]
- Blood sugar effects: GH can affect glucose metabolism; monitoring is recommended [2]
Do not use if you:
- Are allergic to CJC-1295, Ipamorelin, or any ingredients
- Are pregnant or breastfeeding
- Have active cancer or history of certain cancers (GH can promote cell growth) [2]
- Have known hypersensitivity to GHRH or related compounds
⚠️ Warning: Neither CJC-1295 nor Ipamorelin is FDA-approved for any indication. These are research compounds. If you experience severe allergic reactions, difficulty breathing, or signs of anaphylaxis, seek immediate medical help.
📚 References
- CJC-1295 NO DAC Product Page. Beverly Hills Rejuvenation Center. 2025. [2]
- CJC-1295 Ipamorelin Dosage Protocol: Complete Clinical Guide. Perfect B. 2026. [4]
- What Is the Best Way to Use CJC-1295 and Ipamorelin Together? ExcelMale Forum. 2026. [5]
- Best Peptides for Bodybuilding: Ranked by Goal. ScienceInsights. 2026. [9]
- FDA Evaluation of CJC-1295-related bulk drug substances for 503A Bulks List. 2024. [11]
This information is for educational and research purposes only. Always consult with a qualified healthcare professional.
Last updated: July 2026