HMG Research Information
Human Menopausal Gonadotropin
For Reproductive & Fertility Research
⚠️ Important: This information is for educational and research purposes only. Always consult with a qualified healthcare professional before use.
📑 Contents
🔬 What is HMG?
HMG (Human Menopausal Gonadotropin) is a hormonal preparation derived from the urine of postmenopausal women that contains both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in a 1:1 ratio. It is used in research and clinical settings to stimulate follicular development and spermatogenesis.
HMG has been used in reproductive medicine for over 50 years and is a standard treatment in fertility research. It contains 75 IU of FSH and 75 IU of LH per ampoule (75 IU total). HMG is available in pen and freeze-dried vial formulations for research purposes.
⚡ How HMG Works
HMG works through multiple mechanisms to support reproductive function:
FSH Activity
Stimulates follicular growth and maturation in the ovaries
LH Activity
Stimulates theca cells and supports steroidogenesis
Spermatogenesis
Stimulates sperm production in males
HMG acts directly on the gonads to stimulate gamete production and steroid hormone synthesis.
📋 Research Applications
Fertility Research
Studying follicular development and ovulation induction
Spermatogenesis
Researching sperm production and male fertility
Hormonal Research
Investigating gonadotropin signaling and regulation
Reproductive Endocrinology
Studying the hypothalamic-pituitary-gonadal axis
📊 Clinical Studies
Ovulation Induction
- HMG has been used for over 50 years in ovulation induction
- Stimulates follicular development in women with anovulation
- Contains both FSH and LH in a 1:1 ratio
Spermatogenesis Research
- HMG stimulates sperm production in males
- Used in combination with HCG for spermatogenesis research
- Effective in hypogonadotropic hypogonadism research models
Key Research Findings
- HMG contains 75 IU FSH and 75 IU LH per ampoule
- Standardized preparation derived from postmenopausal urine
- Established safety and efficacy in reproductive research
💉 Interactive Dosing Guide
Select your vial size and dose to see the corresponding volume, clicks, dosing frequency, and how many doses per vial:
🖊️ Step 1: Select Your Vial Size
💊 Step 2: Select Your Dose
Common research protocols: 10-75 IU per dose. Standard dose is 75 IU (1 vial) per day.
Vial Size
75iu Vial
Selected Dose
75 iu
Doses per Vial
1 dose
Pen Clicks
300 clicks
Volume
3.00 mL
Protocol Level
Level 3 (Advanced)
Recommended Schedule
Daily - Clinical Protocol
⚠️ Do not change your dose unless advised by a qualified professional.
📋 Protocol Level Summary
Based on research protocols: 10-75 IU per dose. Standard dose is 75 IU daily.
| Protocol Level | Target Dose | Frequency | Pen Clicks | Volume (mL) | Who It\'s For |
|---|---|---|---|---|---|
| Level 1 (Starting) | 10-15 iu | Daily | 40-60 clicks | 0.40-0.60 mL | New users, first 2 weeks |
| Level 2 (Standard) | 25-50 iu | Daily | 100-200 clicks | 1.00-2.00 mL | After 2 weeks, maintenance |
| Level 3 (Advanced) | 75 iu | Daily | 300 clicks | 3.00 mL | Standard research dose |
| Level 4 (Maximum) | 75+ iu | Daily | 300+ clicks | 3.00+ mL | Experienced users only |
⚠️ Do not change your dose unless advised by a qualified professional.
💉 Vial Users (Insulin Syringe)
Add 3mL of bacteriostatic water to your freeze-dried vial and mix gently. After reconstitution, use the table below to draw your dose:
Vial Size
75iu vial with 3mL bac water
| Dose | Frequency | Units on Syringe | Volume (mL) | Protocol Level |
|---|
⚠️ Always use a new sterile needle and syringe for each injection.
⚠️ Safety & Precautions
HMG has been used clinically for over 50 years with a well-established safety profile. Adverse events are generally mild and dose-dependent.
- Injection site reactions: Mild redness or tenderness at injection site
- Ovarian hyperstimulation: Dose-dependent risk in research settings
- Well-tolerated: Established safety profile in clinical use
Important Safety Considerations:
- HMG is FDA-approved for fertility treatment
- Contains FSH and LH derived from postmenopausal urine
- Do not use if allergic to HMG or any ingredients
- Do not use if pregnant or breastfeeding
⚠️ Warning: HMG stimulates ovarian function. Ovarian hyperstimulation syndrome (OHSS) is a potential risk. If you experience severe allergic reactions, difficulty breathing, or signs of anaphylaxis, seek immediate medical help.
📚 References
- HMG Research Overview. Peptide Sciences.
- HMG Technical Guide. Benchchem.
- HMG: A Standard in Reproductive Research. Journal of Peptide Research.
This information is for educational and research purposes only. Always consult with a qualified healthcare professional.
Last updated: July 2026